BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

The first six chapters of this book present and criticize six views of the nature of proper names, among which are theories that proper names have no meaning or connotation, that proper names have more meaning than other signs or that their meaning is infinite, that ordinary proper names should be analysed into "logically" proper names, etc. This part of the book is the best. One may find in these chapters several well-reasoned arguments which seem to totally demolish the theories (...) under investigation. Chapters seven to nine present the author's own solution to the problem. Sørensen holds that a proper name does have a meaning—otherwise it would not have been a part of language at all. The meaning of a linguistic sign, he argues, is a set of conditions to be satisfied by an extra-linguistic entity, such that this entity may be identified as denoted by the said sign. A proper name is an individual name, and its meaning is a series of necessary and sufficient conditions for the identification of the individual entity which this name is intended to denote. It is Sørensen's view that this series consists of a definite description of final length including space and time indicators. The definiens formula for proper names is thus 'P' = 'the x that... t... p....' The discussion of this proposal is, however, greatly impaired by Sørensen's utter disregard for the rich philosophical literature existing on the subject: no attempt is made to confront his view with the now standard arguments against theories of that type. Even many inner difficulties of the proposed solution are ignored. E.g., one may ask what values do 't' and 'p' take in the definition of 'Zeus'. Or take the following puzzle: are 'The x that taught Aristotle in p at t' and 'The x that studied with Socrates in p at t' both the meaning of 'Plato'? Sørensen's view that "A national register may be looked upon as a dictionary of proper names" suggests a positive answer, but surely R and S cannot be the same meaning. Many similar problems bother the reader of Sørensen's book, but, unfortunately, they are nowhere discussed.—E. M. Z. (shrink)

A book which might well become a classic on Heidegger. Richardson discusses most of Heidegger's works in chronological order, offering a close analysis of each. Most chapters include a general exposition of the argument of the work discussed, a detailed analysis of the problems of Thought, Being and Dasein in the work, and a résumé. While maintaining very high standards of scholarly precision in the rendering of Heidegger's ideas and terminology, Richardson yet succeeds in making his book very readable and (...) lucid. Without "supplementing" Heidegger in any way, refraining from explanatory speculations and staying always very close to the text, he manages to clarify some of the most difficult passages of Heidegger's works. His frequent cross-references make the commentary of genuine value to the advanced student as well as to the novice. Heidegger, in his own preface to the book, criticizes Richardson for the sharp distinction between Heidegger I and Heidegger II, but gives a most important substantiation to two of the author's main theories, viz., the difference between Heidegger's Seinsdenken and Husserl's phenomenology, and the central status of the concept of Ereignis in Heidegger's philosophy. Richardson regrettably does not pursue the Heidegger III suggested by Vycinas, the Heidegger of the Geviert, the question of the nature of Being as such. In some chapters at least this omission makes the interpretation seem partial and sometimes inexact. One hopes for a sequel as good and illuminating.—E. M. Z. (shrink)

The book can be roughly divided in two parts. The first four chapters criticize several previous systems of aesthetics, notably those of Cassirer, Croce, and their followers, and suggest an alternative based upon an interesting extension of the recently, much-discussed theory of direct perception as a "seeing-as." Hofstadter would use this model of interpretative-perception to explicate the nature of language as well. A cry will not be, thus, an "expression" of pain but rather present the pain directly; it would articulate (...) human existence in a certain way. Accepting, in addition, the idealistic theory of Categories, Language is understood by Hofstadter as the emergence of the self and the world into a meaningful and an intelligible existence. The next three chapters which, to my mind, make the weaker part of the book, distinguish three kinds of language and, hence, three kinds of truth. There is the truth of statement, which is explicated as the identity of the meant with the existent, the truth of things, which is the practical governance of things by the self's laws and ends, and the truth of spirit, being the synthesis of the former two, where the thing reaches a full realization of its own will of being. When the life-will brings itself to full realization, the thing is perfect, i.e., it is beautiful. It is unfortunate that in the development of these important and highly interesting ideas rhetoric often takes the place of philosophical rigor. The concluding chapter, exploring "the spiritual truth of art," gives a coherent application of the theory and combines a dialogue with several aestheticians, critics, and artists with an analysis of some crucial problems in aesthetics.—E. M. Z. (shrink)

A collection of commentaries on various theories in aesthetics, similar in method and aim to Kainz's Vorlesungen. Far from placing "the study of aesthetics on a new footing" or grasping "the scope of the subject as a whole," as the dust jacket declares, it is still a useful, well organized and often illuminating manual for the student of aesthetics. Sparshott treats some problems clearly and succinctly, but many other questions, such as the mode of being of the work of art (...) or the possibility of regarding art as a cognitive form, are not even mentioned. It also seems that some familiarity with at least the main currents in aesthetics on the continent and a more systematic conception of the field of aesthetics as a whole would have brought Sparshott closer to his stated aims.—E. M. Z. (shrink)

A brief, non-technical, well-organized presentation of a system of aesthetics which makes use of insights typical of various Gestalt psychologists and phenomenologists but claims Wittgenstein and the school of language analysis as its only source of influence. Works of art as well as the materials the artist uses are subject to "aspection" and "animation" by various images, such that "each material is featured as a little, elementary aesthetic object." Aldrich offers a theory of evaluations and normative descriptions of works of (...) art, showing that they are not purely subjective or arbitrary. Several important issues remain quite vague throughout the book, e.g., the concept of "holophrastic perception" which is supposed to give us the nature of the "material thing" as it really is. There is a complete lack of interest in anything done in aesthetics by continental philosophers.--E. M. Z. (shrink)

Unlike most anthologies in aesthetics and the philosophy of art, the present selection does not try to collect representative extracts from the writings of most, or even many, important aestheticians throughout the ages. It aims for depth rather than width and tries to do as much justice as possible to those aestheticians which it does include, without bothering much about those left out. The result is really impressive. No less than 138 pages are devoted to Plato and Aristotle alone, where (...) the reader may find not only the usual passages from the Poetics and the Rhetoric but also relevant material from De Partibus Animalium and Politica. Such an anthology, so it seems, must be an opinionated one. Thus, while it contains some 70 pages of Dewey's Art as Experience, there is not a single line of Santayana in it. Although I disagree with the choice made in this case, I cannot but admire the courage it took to make it. Another surprise is the inclusion of the relatively obscure mediaeval thinker, Marsilio Ficino, in an anthology which excludes Baumgarten, Lessing, Burke, Schiller, Coleridge, Bosanquet and Alexander, to mention but few, and whose sole contemporary representative is Heidegger. The extracts from Ficino's commentary on Plato prove, however, to be highly interesting and relatively original, too. Thus, even if Ficino is not as great as some of the aestheticians not included in this volume, I, for one, would not regret this mark of personal, off-beat, taste. The last selection, Heidegger's "The Origin of the Work of Art," appearing for the first time in English translation, comes as special bonus to the reader. The editors' introductions to each selection are generally concise, precise, and very helpful. Sometimes, however, one may find an exception: in their introduction to the Heidegger translation, the editors characterize the Kehre as a "reversal... from the stress on anxiety, nothingness... to a stress on more affirmative moods." This is, to say the least, a grossly misleading remark, which is likely to confuse the student of the later Heidegger rather than help him.—E. M. Z. (shrink)

The complexity of biobank research raises concerns about individuals’ understanding of the information conveyed in the consent process for such research.. We report the results of a qualitative, cognitive interview study with an ethnically, linguistically, and educationally diverse sample of 43 respondents to assess the clarity and utility of a multimedia tool developed for a biobank. Using weighted randomization, respondents were assigned to either view the multimedia tool or read a written consent document . The study illustrates the utility of (...) cognitive interviews for gaining insights from prospective research participants about the clarity of informed consent tools. Findings suggest that a multimedia tool is useful for communicating key messages but should be combined with a written consent document and personal interaction with the study staff. We recommend that the potential value of multimedia tools should be more rigorously tested in a randomized controlled trial. (shrink)

Parry’s volume is not an elementary book, but it is apparently intended as an introduction to Locke’s political thought for students. While he definitely has a point of view of his own, he attempts to draw together much of the recent critical thought on Locke. Parry’s volume differs from much of the recent work on Locke in being, one might say, "sweet-tempered." He is sweet-tempered in the first place toward Locke. Unlike so much of the recent scholarly-historical literature, he clearly (...) respects Locke. In a field marked by acrimony among scholars, Parry is also remarkably sweet tempered toward other Locke scholars; he builds on the work of others where possible, rather than emphasizing his own novelty and uniqueness. He thus produces a far more balanced treatment than most. For example, he accepts willingly the Laslett-sponsored arguments that the Second Treatise is aimed against Filmer as was the First, but he refuses to toss out entirely the older view that it is aimed in some measure against Hobbes. Although Parry is probably least tolerant towards the Strauss approach to Locke, he is even able to find large areas where he endorses moderate versions of that position, for example, on the important range of similarities between Hobbes and Locke. Parry’s "harmonizing approach" shows up also in the unusually wide range of Lockean sources from which he draws. He uses not only the standard fare of the Second Treatise and the Essays on the Law of Nature, but also the works on education, toleration, and economics to good effect. Disappointingly scanty, however, is the place of the First Treatise and even the Essay. His harmonizing approach shows up most importantly, however, in his attempt to combine the two chief sorts of attention Locke has received in recent years. On the one hand, there is the Locke scholarship properly so-called. While there are several varieties and orientations within this literature, no doubt the leading one has taken a very historical approach—attempting to understand Locke in his historical context and deploying religious or theological categories as the chief means for doing so. This approach shuns "present-mindedness" above all other intellectual vices. While Parry announces his general adherence to this approach he attempts to take account of the other main sort of interest in Locke today—as a source and inspiration for a very live contemporary tradition of political thinking, represented by Nozick and Rawls. Parry uses these contemporary "Lockeans" to help interpret the Second Treatise, leaning for example on Rawls’s formulation of the problem social contact theory attempts to answer, and Nozick’s doctrine of "entitlements." Parry’s refusal to be terrified by the strictures against "present-mindedness" produce some of the best and most valuable features of the book, as when he seriously asks what Locke means today, or how other contemporary political views differ from Locke’s. On the other hand, his reading of Locke on political economy suffers a bit perhaps from over-domination by Nozick’s restatement. Parry attempts to give both devils their due by agreeing with the historical school that Locke’s thought must be read historically, as Christian or theological, in a form that could hardly be acceptable to any contemporary political thinkers, and agreeing with the contemporary Lockean tradition that "to a very considerable extent" Locke’s position "can and must be…assessed and understood apart from its theological substructure." Those theological foundations are, Parry admits, very problematical. In fact, with a post-Humean eye, "it can become difficult to persuade oneself even that Locke could have found his position consistent." Yet Parry affirms "there is no doubt that Locke found the argument satisfying." But he supplies no reason—other than the fact that Locke deployed such arguments on more than one occasion—for this conclusion. Surely gross inconsistencies in argument are grounds for doubt. Parry should have at the least entertained Leo Strauss’s hypothesis about Locke’s manner of expression in light of his own views that Locke’s expressed theological underpinnings are unacceptable philosophically, and that Locke’s position can rest on altogether independent nontheological grounds. Moreover, Parry’s concession that Locke cannot move successfully from those religious underpinnings to the all-important content of the law of nature supplies further grounds for considering the same hypothesis. Parry’s treatment shares with most of the historical approaches to Locke the defect of "slackness"—when we come to something inconsistent or difficult to understand, we write it off as the product of Locke’s faith, internally meaningful, believable to him. Only in Parry’s case this is more problematical yet, for he rightly insists that we see Locke’s position as nonarchaic, and thus makes the reader eager for probing analysis and justification rather than loose appeals to Locke’s times. In order to connect the theological underpinnings to the political arguments, Parry is driven to some most un-Lockean notions such as the duty of "an individual to stretch himself to the full." For a similar reason, we suspect, freedom, which plays an extremely large part in Parry’s exposition, nowhere receives an adequate rooting in Locke’s discussion in the Essay, nor does Locke’s hedonism play a sufficient part in Parry’s interpretation.—M.Z. (shrink)

A repulsive core force is derived which, assuming π mesons are the field particles, gives binding energies in good agreement with binding energies per nucleon of heavy nuclei. The physical model consists of a field of relatively short range, in which emission of a π meson by a nucleon and subsequent absorption by a neighboring nucleon is equivalent to a potential well. The binding energy at the equilibrium spacing of the nucleons is the self-energy of the π mesons, which is (...) calculated by analogy with classical electric fields. (shrink)

Although some of Helmholtz’s scientific suggestions are dated with the progress of science, his ontological statements as well as his epistemological studies are still an object of philosophical controversy. The selection of Helmholtz’s epistemological writings, edited as volume 79 in the Synthese Library, contains four papers originally published in German between 1868 and 1887. In these papers are considered among others the epistemological aspects of measuring and numbering, the issues of perceptual cognition, the theory of geometrical knowledge, and the relationship (...) between science and metaphysics. The present collection of the Helmholtz’s articles was previously edited in German, on the centenary of his birth, under the title Schriften zur Erkenntnistheorie. The editors, M. Schlick and P. Hertz, sharing the opinion that Helmholtz’s name is a symbol of a union between epistemologically oriented philosophy and science, had selected from his many epistemological writings only four—the most representative and the most complete. In order to make the papers intelligible not only to philosophers but also to general readers, Schlick and Hertz supplemented the primary texts with explanatory remarks and comments. Some of them have a general introductory character, explaining, for instance, the difference between induction and deduction or elucidating Locke’s conception of two kinds of properties; the others present useful syntheses of methodological solutions, comparing, e.g., Carnap’s or Reichenbach’s ideas with Helmholtz’s. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

This book contains twenty-two papers by K. Ajdukiewicz, an outline of his memoir and philosophical evolution by J. Giedymin, and a bibliography of Ajdukiewicz’s works compiled by T. Czezowski. In the colorful introductory paper, Giedymin characterizes the personality of the famous Polish philosopher-logician as a person open not only to philosophical investigations but also to contemplation of the beauty contained in music, literature, and nature. The sketch of Ajdukiewicz’s scientific activity presents him as an excellent teacher, open-minded in understanding different (...) viewpoints but simultaneously as an independent and uncompromising thinker. (shrink)

Rudolf Carnap, remembering in his Autobiography a visit to Warsaw in November 1930, and recalling animated discussions with Lesniewski, Kotarbinski, and Tarski, expressed deep regret that stimulating and fruitful works in the field of logic and theory of knowledge, published only in the Polish language, were inaccessible to the philosophical world. An analogous opinion is expressed by Karl R. Popper who has stated that his methodological solutions were influenced by Alfred Tarski more than by anybody else. Regarding similar appraisals and (...) trying to partially eliminate the mentioned barrier of the language, D. Reidel Publishing Company has edited an anthology of methodological papers published in Poland between 1947-72. The anthology consists of thirty-three articles by twenty Polish logicians investigating the issues of the general methodology of empirical sciences. (shrink)

To consider power as not only the direct physical oppression of others, but as a production of authority through discursive knowledge and a claimed ‘expertise’ of the world, has been one of Foucault’s great legacies to critical work on mental health and illness. As arbiters of the ‘truth’ on what is and what is not mental pathology, I agree with Swerdfager that the privileged knowledge of the mental health professions and the consequential marginalization of other forms of knowledge on distress (...) can be better theorized through an investigation of the power/knowledge nexus. Practically, scholars and researchers can begin to address these... (shrink)

Tuberculosis (TB) is a potentially fatal infectious disease that, in Aotearoa New Zealand (NZ), inequitably affects Asian, Pacific, Middle Eastern, Latin American, and African (MELAA), and Māori people. Medical research involving genome sequencing of TB samples enables more nuanced understanding of disease strains and their transmission. This could inform highly specific health interventions. However, the collection and management of TB isolate samples for research are currently informed by monocultural biomedical models often lacking key ethical considerations. Drawing on a qualitative kaupapa (...) Māori–consistent study, this paper reports on preliminary discussions with groups of Māori, Pacific, and Afghan people in NZ, whose communities have been harmed by TB and TB stigma. Participants’ discussions highlight key concerns and meanings that ought to inform the development of guidelines and a more robust consultative process for the governance of how TB isolate samples are collected and used both retrospectively and in future research. We argue for ethical processes to be culturally nuanced and community-generated, flexible and meaningful, and situated in relation to the physical and symbolic effects of TB. We discuss the significance of Indigenous data sovereignty, rights, and kāwanatanga (governorship) in shaping a multicultural data sovereignty model. (shrink)

BackgroundClinical ethics consultations can be complex interventions, involving multiple methods, stakeholders, and competing ethical values. Despite longstanding calls for rigorous evaluation in the field, progress has been limited. The Medical Research Council proposed guidelines for evaluating the effectiveness of complex interventions. The evaluation of CEC may benefit from application of the MRC framework to advance the transparency and methodological rigor of this field. A first step is to understand the outcomes measured in evaluations of CEC in healthcare settings. ObjectiveThe primary (...) objective of this review was to identify and map the outcomes reported in primary studies of CEC. The secondary objective was to provide a comprehensive overview of CEC structures, processes, and roles to enhance understanding and to inform standardization.MethodsWe searched electronic databases to identify primary studies of CEC involving patients, substitute decision-makers and/or family members, clinicians, healthcare staff and leaders. Outcomes were mapped across five conceptual domains as identified a priori based on our clinical ethics experience and preliminary literature searches and revised based on our emerging interpretation of the data. These domains included personal factors, process factors, clinical factors, quality, and resource factors. ResultsForty-eight studies were included in the review. Studies were highly heterogeneous and varied considerably regarding format and process of ethical intervention, credentials of interventionist, population of study, outcomes reported, and measures employed. In addition, few studies used validated measurement tools. The top three outcome domains that studies reported on were quality, process factors, and clinical factors. The majority of studies examined multiple outcome domains. All five outcome domains were multidimensional and included a variety of subthemes.ConclusionsThis scoping review represents the initial phase of mapping the outcomes reported in primary studies of CEC and identifying gaps in the evidence. The confirmed lack of standardization represents a hindrance to the provision of high quality intervention and CEC scientific progress. Insights gained can inform the development of a core outcome set to standardize outcome measures in CEC evaluation research and enable scientifically rigorous efficacy trials of CEC. (shrink)

Recent data indicate that under a specific posthypnotic suggestion to circumvent reading, highly suggestible subjects successfully eliminated the Stroop interference effect. The present study examined whether an optical explanation could account for this finding. Using cyclopentolate hydrochloride eye drops to pharmacologically prevent visual accommodation in all subjects, behavioral Stroop data were collected from six highly hypnotizables and six less suggestibles using an optical setup that guaranteed either sharply focused or blurred vision. The highly suggestibles performed the Stroop task when naturally (...) vigilant, under posthypnotic suggestion not to read, and while visually blurred; the less suggestibles ran naturally vigilant, while looking away, and while visually blurred. Although visual accommodation was precluded for all subjects, posthypnotic suggestion effectively eliminated Stroop interference and was comparable to looking away in controls. These data strengthen the view that Stroop interference is neither robust nor inevitable and support the hypothesis that posthypnotic suggestion may exert a top-down influence on neural processing. (shrink)

Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

This qualitative research study with a content analysis approach aimed to explore families’ experiences of an organ donation request after brain death. Data were collected through 38 unstructured and in-depth interviews with 14 consenting families and 12 who declined to donate organs. A purposeful sampling process began in October 2009 and ended in October 2010. Data analysis reached 10 categories and two major themes were listed as: 1) serenity in eternal freedom; and 2) resentful grief. The central themes were peace (...) and honor versus doubt and regret. The findings indicated that the families faced with an organ donation request of a brain-dead loved one experienced a lasting effect long after the patient's demise regardless of their decision to donate or refusal to donate. In conclusion, this study highlights the importance of family support and follow-up in an efficient healthcare system aimed at developing trust with the families and providing comfort during and after the final decision. (shrink)

A recent article in this journal described practical and conceptual difficulties faced by public health researchers studying scabies outbreaks in British residential care facilities. Their study population was elderly, decisionally incapacitated residents, many of whom lacked a legally appropriate decision-maker for healthcare decisions. The researchers reported difficulties securing Research Ethics Committee approval. As practicing healthcare ethicists working in a large Canadian research hospital, we are familiar with this challenge and welcomed the authors’ invitation to join the discussion of the ‘outstanding (...) ambiguities and further questions’ that their experience uncovered. We propose a Power of Attorney for Research as one substantive solution to help address the problems they identified. Although we acknowledge the familiar shortcomings associated with Advance Directives in the clinical context, we believe that Powers of Attorney for Research Participation, accompanied by Advance Research Directives, may increase the likelihood of gaining deeper understandings of potential participant’s values and priorities and how they might apply to foreseeable research opportunities. (shrink)

Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

We use joint probabilities to analyze the EPR argument in the Bohm's example of spins.(1) The properties of distribution functions for two, three, or more noncommuting spin components are explicitly studied and their limitations are pointed out. Within the statistical ensemble interpretation of quantum theory (where only statements about repeated events can be made), the incompleteness of quantum theory does not follow, as the consistent use of joint probabilities shows. This does not exclude a completion of quantum mechanics, going beyond (...) it, by a more general theory of single events, using hidden variables, for example. (shrink)

Coastal ecosystems are increasingly dominated by humans. Consequently, the human dimensions of sustainability science have become an integral part of emerging coastal governance and management practices. But if we are to avoid the harsh lessons of land management, coastal decision makers must recognize that humans are one of the more coastally dependent species in the biosphere. Management responses must therefore confront both the temporal urgency and the very real compromises and sacrifices that will be necessary to achieve a sustainable coastal (...) ecosystem, one that is economically feasible, socially just, and ecologically sound. (shrink)

A child’s death is a profound loss for mothers and affects hundreds of thousands of women. Mothers report inconsolable and progressive grief that is distinct from depression and impacts daily emotions and functions. The brain mechanisms responsible for this relatively common and profound mental health problem are unclear, hampering its clinical recognition and care. In an initial exploration of this condition, we used resting state functional MRI (fMRI) scans to examine functional connectivity in key circuits, and task-based fMRI to examine (...) brain network activity in grieving mothers in response to pictures of their deceased child and as well as recognizable deceased celebrities and unfamiliar individuals. We compared nine mothers who had lost an adult child and aged-matched control mothers with a living child of a similar age. Additionally, we collected diffusion imaging scans to probe structural connectivity and complemented the imaging studies with neuropsychological assessments. Increased functional activation in Ventral Attention/Salience Networks accompanied by a reduced activation in the medial prefrontal cortex in response to the deceased child’s picture robustly distinguished the grieving mothers from controls. Heightened resting-state functional connectivity between the paraventricular thalamic nucleus (PVT) and the amygdala distinguished the grieving mothers from the controls and correlated with subjective grief severity. Structurally, maternal grief and its severity were associated with alterations in corticolimbic white matter tracts. Finally, grieving mothers performed worse than controls on neuropsychological tests of learning, memory, and executive function, linked with grief severity. Reduced activation in cortical regions inhibiting emotions and changes in the PVT circuitry—a region involved in long-term emotional memories and decision making under conflict—distinguish grieving mothers from controls. Notably, the magnitude of neurobiological changes correlates with the subjective severity of grief. Together, these new discoveries delineate a prevalent and under-recognized mental health syndrome and chart a path for its appreciation and care. (shrink)